Sleep Disturbances Linked to Alzheimer's Disease

Sleep Disturbances Linked to 

Alzheimer's Disease

By Diderique Konig
Thu, Mar 28, 2013

Adults who have certain sleep quality disturbances may be experiencing 

very early signs of Alzheimer’s disease.

One study published on MedPageToday.com was conducted by 

Washington University School of Medicine in St. Louis and “studied 

142 cognitively normal people, ages 45 and older, taking part in 

long-term studies of memory and aging.”

Researchers studied the amount of time spent in bed and the actual 

amount of sleep people got each night for two weeks.

Researchers discovered that participants who had high levels of beta-

amyloid42 in the cerebrospinal fluid were at an increased risk for 

amyloid depositions.

Amyloid depositions have been linked to the development of 

Alzheimer’s disease. According to ScienceNow, “In both humans and 

mice, levels of a peptide called amyloid-? rise during waking hours and 

decline during sleep, researchers have found. They also report that 

sleep-deprived mice are more prone to developing deposits of amyloid?

called plaques, like those found in the brains of Alzheimer's patients. 

Although far from proven, the finding suggests that sleep disorders 

could be a risk factor for Alzheimer's.”

While Amyloid-? is found naturally in the brain, an abundance of this 

molecule may lead to Alzheimer’s later on in life.

In studies, sleep deprivation raised the levels of amyloid-? molecules 

and created more clusters of this molecule in the brain.

“Experiments at Washington University showed that nocturnal mice slept 

for 40 minutes during every hour of daylight. However, as soon brain 

plaques started to form the mice were sleeping for only 30 minutes.The 

findings suggest that people who are chronically sleep deprived may 

have higher levels of amyloid-? that make them more susceptible to 

Alzheimer's disease,” according to a BBC News article.

Sleep patterns in Alzheimer’s patients are often already affected and 

tend to get worse as the disease advances, so taking proper precautions 

is key.

In those people already diagnosed with the disease, sleep disturbances 

can be caused by factors such as anxiety, depression, restless leg 

syndrome, or even having inadequate lighting in the room.

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